The fifth: Sleep and hormone- relationship between orexin and drowsiness-

睡眠と覚醒のメカニズム(3)~3つのシステム―メラトニン | オレキシン | 恒常性調節系~
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Top specialist

Hiroshi Bando

medical doctor

Councilor of the Japanese Society of Anti-Aging Medicine

Director of Shikoku Branch of Japan Society for Integrated Medicine

In this series, we teach you the tips for a good night's sleep.

Last month I touched on the mechanism of sleep and awakening.

inside that,

  • Melatonin works on sleep and wake rhythms

  • Fish and chickens also have a "third eye" that feels light

  • Models include "Chakra" in integrative medicine, the science fiction comic "The Three-Eyed One", and Ultraseven's beam lamp.

And so on.

Next, let's talk about the hormonal mechanism for sleep this month.

- table of contents -

1. Eating and sleeping Affecting orexin-hormones related to sleep and arousal-

 
概日リズム(サーガディアンリズム)

You may have become sleepy after eating a lot.

On the other hand, if you get hungry or if you use your body clock in the morning, your eyes will be refreshed.

For this

  • Metabolic system of glycemic fluctuation

  • Nervous system

  • Hormonal system

Many mechanisms are involved.

Hormone "orexin" that is closely related to sleep

With the development of medical research, the hormone "orexin" secreted from the hypothalamus has been discovered.

The name comes from the Greek word (orexis), which means appetite.

After that, it turned out to play an important role in the work of sleep and awakening.

Orexin issues a wide range of commands as shown in the figure.

洞窟でクラスと体内リズムが狂い、24時間から25時間へ

Case chart

Sleep / wake cycle shifts from 24 hours to 25 hours

Then, the organization that received the command (receptor) awakens crisply and does various tasks properly.

So to speak, it may be said that they are willing to do good deeds for the sake of the world.

Because it means "I donate" in Japanese.

非24時間睡眠覚醒症候群
非24時間睡眠覚醒症候群

Figure 1 shows a 24-hour sleep rhythm , but Figure 2 shows a 25-hour sleep rhythm .

You can see that the sleep-wake rhythm is off by one hour every day.

 

This is difficult in jargon, but it is a condition called "non-24-hour sleep-wake syndrome."

2. To awakening with high hunger and feelings-Three elements that promote awakening-

 
シャキッと覚醒

There are three major factors that activate the orexin.

  • Stimulation of hunger in nutritional status

  • Stimulation that it was morning with the body clock

  • Stimulation that feelings were high in the psychological state

When these stimuli are received, orexin secretion increases and the state of arousal is maintained.

In other words, the presence of orexin allows the brain to wake up and be active .

On the other hand, if the action is weak, you will not be able to maintain your wakefulness and will fall asleep.

There is also a related illness called narcolepsy that causes you to fall asleep suddenly.

ホルモン「オレキシン」分泌により覚醒-視床下部

If you compare it to a movie, it's a tape recorder that records commands from the organization.

The situation is the same as when it is delivered to 007.

The command disappears quickly, but the received 007 awakens crisply.

The reason for doing work by working your head from multiple angles.

 

If, if this command is, you might stimulation fall asleep without.

 

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オレキシン活性化→覚醒
オレキシン減少→安眠

There are three major factors that stimulate the orexin.

 

① Stimulation of hunger in nutritional status

② Stimulation that it was morning with the body clock

③ Stimulation that feelings were high in the psychological state

 

When these stimuli are received, orexin secretion increases and the state of arousal is maintained .

As shown in the figure below, it keeps a good balance like Weeble.

健常者の覚醒状態

Once your Rekishin secretion is reduced to the contrary, waking → to advance in the direction of sleep.

 

In this regard, everyone has something to experience on a daily basis.

If you eat too much delicious treat, you will get drowsy afterwards.

 

This can be said to be the work of orexin.

 

When the blood sugar level rises due to the sugar contained in the diet,

Glucose concentration in cerebrospinal fluid will also increase.

Then, the activity of the neurons that activate orexin temporarily weakens, so

It makes me sleepy.

満腹で眠くなる赤ちゃん-オレキシンの睡眠作用

3. Good sleep when receptor block-Mechanism of sleeping pills-

 

In order for orexin to work, it must bind to a site called the orexin receptor.

This mechanism is used to block the orexin receptor in advance with a drug.

Then, it suppresses the increased wakefulness and brings sleep.

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Suvorexant is an orexin receptor antagonist and is prescribed under the name "Versomura".

Belsomra means "beautiful sleep" and is derived from belle (beautiful) + som (sleep) .

In French, sleep is called sommeil and sleep is called sommeiller.

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Last time and this time, I outlined melatonin receptor agonists and orexin receptor antagonists , and summarized the important points below.

With a thorough understanding of these, it is possible to take medication if necessary.

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Brahms's "Sleeping Spirit" has been known as a lullaby-like song.

 

From ancient times, it has been said that when a sleeping fairy puts sand on a child's eyes, he is invited to a good night's sleep.

It would be great if you could have a good dream while being embraced by music that heals your mind.

4. Sleep well-Let's rejuvenate for tomorrow-What you can do before taking medicine-

 

The order in which you think about getting a good night's sleep is

① Regular lifestyle

② Maintaining an appropriate mental and physical condition by each person

③ Utilize "sound medicine" that uses music well

④ Drugs if necessary

Please refer to.

The proverb "Sleep and wait for good luck" is famous.

I pray that a good night's sleep will lead to a good life (every day, life, life).

メラトニン受容体作用薬-ロゼレム
オレキシン受容体拮抗薬-ベルソラム

However, in terms of working in good physical and mental health,

It is best to make good use of the medicine " sound medicine" called music.

音薬の効果-音楽がもたらす効果-意識・前意識・無意識に作用する

* Please refer to the 1st column for the effects of music on sleep.

Best sleep-a good sleep column by top specialists

The 5th serialization was "Sleep and Hormones-Relationship between Orexin and Sleep" by Dr. Hiroshi Bando .

  1. Eating and sleeping Affecting orexin-hormones related to sleep and arousal-

  2. To awakening with high hunger and feelings-Three elements that promote awakening-

  3. Good sleep when receptor block-Mechanism of sleeping pills-

  4. Sleep well and rejuvenate for tomorrow-What you can do before taking medicine-

Recommended music this time

Continuing from the last time, we will introduce healing music that activates the "pineal gland" and promotes melatonin production.
A gentle tone reaches the pineal gland and gives deep healing and sleep.

It is a healing album to promote metabolism and sleep beautifully.
The natural afterimage sound of the live piano recording performed in the concert hall creates a blissful healing space.

Please use "sound medicine" and spend a healthy life.

Recommended videos

U-NEXT-SID0051014-15 Minute Relaxation-沖縄・自然音-【RELAX WORLD】.jpg

Please spend a relaxing rest time with the natural sounds of Okinawa and the beautiful scenery.

★ The next theme is "sleep and brain waves". Please look forward to it!

[Top Specialist Profile]

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Hiroshi Bando

Doctor of Medicine Councilor, Japan Society for Anti-Aging Medicine Representative, Tokushima Prefecture Sugar Restriction Study Group

After graduating from Tokushima University and obtaining ECFMG qualification, clinical training in family medicine in the United States. Areas of expertise include anti-aging, carbohydrate restriction, music therapy, and sports medicine. Participated in the national polity as an ice skater (1999-2003). President of the 9th Annual Meeting of the Japanese Society of Music Therapy (2009). The 3rd European International Piano Competition (EIPIC) in Japan Silver Award (2012). President of the Japan Primary Care Association (2017, Takamatsu).
Editor-in-Chief (Editor-in-Chief, 2020) of four English medical journals related to diabetes. Over 30 books, over 2,000 printed matter, over 200 English treatises. Representative of Tokushima, "New Elderly Society".

Official site: https://pianomed.org/